Structural characterization of pectin-bismuth complexes and their aggregation in acidic conditions.

Bismuth-contained therapies are effective in treating gastric ulcer and eliminating Helicobacter pylori (Hp). Anion polysaccharides ligand could reduce the intake of bismuth, and enhance drug efficacy of bismuth compounds. In this study, pectin-bismuth (PB) was prepared and the changes of PB structure in acidic environment were reported for the first time. The structure of PB was characterized by FT-IR, XRD, and TGA, which suggested that combined with bismuth could alter the crystal structure of pectin. XPS confirmed the ionic binding of Bi3+ with carboxyl groups of pectin. The aggregating of PB with different pH level were also investigated, and the influence of pH on PB structure were observed by SEM. Results showed that PB has much larger volume of flocculation in acidic environment compared with bismuth nitrate. Additionally, apparent shear stress (τa) of PB suspension was evaluated. These results revealed the structural characteristics and acid-induced aggregation of pectin-bismuth, and bismuth could aggregate in acidic solution with the gelation of pectin. Copyright © 2020 Elsevier B.V. All rights reserved.

Citation

Wen-Xin Jiang, Jun-Ru Qi, Jin-Song Liao, Zhi-Li Wan, Wan-Ling Liang, Jia-Yi Huang, Yong Cao, Jie Xiao, Xiao-Quan Yang. Structural characterization of pectin-bismuth complexes and their aggregation in acidic conditions. International journal of biological macromolecules. 2020 Jul 01;154:788-794

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PMID: 32194115

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