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Insulin-stimulated trafficking of GLUT4 requires the myosin motor Myo1C and signaling adaptor 14-3-3β. Originally, it was thought that 14-3-3β promotes GLUT4 transport by binding the Myo1C lever arm and activating the Myo1C motor. New work by Ji and Ostap using in vitro assays reveals that 14-3-3β binding actually inhibits Myo1C motility, prompting reconsideration of the functional relationship between 14-3-3β and Myo1C and the regulatory potential of atypical light chains. © 2020 Eddington and Titus.


Casey Eddington, Margaret A Titus. Putting the brakes on a myosin motor. The Journal of biological chemistry. 2020 Mar 20;295(12):3757-3758

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PMID: 32198186

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