Correlation Engine 2.0
Clear Search sequence regions


  • 2 3' cyclic gmp (1)
  • amp (3)
  • atp (1)
  • CSK (7)
  • cyclic gmp (3)
  • dna virus (6)
  • gtp (1)
  • humans (1)
  • mice (1)
  • mice knockout (1)
  • protein human (1)
  • signal (1)
  • viral dna (1)
  • Sizes of these terms reflect their relevance to your search.

    Upon detection of viral DNA, the cytoplasmic DNA sensor cyclic GMP-AMP (cGAMP) synthase (cGAS) utilizes GTP and ATP as substrates to synthesize the second messenger molecule 2'3'cyclic GMP-AMP (cGAMP), which binds to the ER-associated adaptor protein MITA/STING to signal innate antiviral response to DNA virus. How the cGAS-MITA pathways are post-translationally regulated is not fully understood. In this study, we identified the tyrosine kinase CSK as a positive regulator of cGAS-MITA mediated innate antiviral response. CSK-deficiency inhibits DNA virus-triggered induction of downstream antiviral effector genes. Following DNA virus infection, CSK phosphorylates MITA at Y240 and Y245, which is important for its activation. These results suggest that CSK plays a role in modulating innate immune response to DNA virus. Copyright © 2020 Elsevier Inc. All rights reserved.

    Citation

    Peng Gao, Ming-Ming Hu, Hong-Bing Shu. CSK promotes innate immune response to DNA virus by phosphorylating MITA. Biochemical and biophysical research communications. 2020 May 21;526(1):199-205

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 32201077

    View Full Text