Geranylgeranyl generosity: a new prenyl-transferase gives a fat to a SNARE protein.

Amy F Roth, Nicholas G Davis

The EMBO journal 2020 Apr 15

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Protein prenylation, a well-defined protein consensus motifs direct modification by one of three prenyl-transferases, has been an area of fairly settled science for 20 or 30 years. Protein prenylation, the specific prenyl modification (farnesyl or geranylgeranyl), as well as the prenyl-transferases involved can be inferred by protein sequence. Two new papers now upset this settled wisdom with the discovery of a fourth prenyl-transferase, namely geranylgeranyl-transferase-III (GGTase-III) (Kuchay et al, 2019; Shirakawa et al, 2020). © 2020 The Authors.

Citation

Amy F Roth, Nicholas G Davis. Geranylgeranyl generosity: a new prenyl-transferase gives a fat to a SNARE protein. The EMBO journal. 2020 Apr 15;39(8):e104744