The role of melanins in melanotic fungi for pathogenesis and environmental survival.

Helene C Eisenman, Edyta M Greer, Carolyn W McGrail

Applied microbiology and biotechnology 2020 May

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Melanins provide fungi protection from environmental stressors, support their ecological roles, and can confer virulence in pathogens. While the function, structure, and synthesis of melanins in fungi are not fully understood, they have been shown to have varied roles. Recent research has revealed a wide range of functions, from radiation resistance to increasing virulence, shedding light on fungal diversity. Understanding fungal melanins can provide useful information, from harnessing the properties of these various melanins to targeting fungal infections.Key Points• Melanotic fungi are widespread in nature. • Melanin functions to protect fungi in the environment from a range of stresses. • Melanin contributes to pathogenesis and drug resistance of pathogenic fungi.

Citation

Helene C Eisenman, Edyta M Greer, Carolyn W McGrail. The role of melanins in melanotic fungi for pathogenesis and environmental survival. Applied microbiology and biotechnology. 2020 May;104(10):4247-4257