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    Double ruthenium(II)-catalyzed alkyne annulations of quinones were accomplished. Thus, a strategy is reported that provides step-economical access to valuable quinones with a wide range of applications. C-H/N-H activations for alkyne annulations of naphthoquinones provided challenging polycyclic quinoidal compounds by forming four new bonds in one step. The singular power of the thus-obtained compounds was reflected by their antileukemic activity. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.


    Eufrânio N da Silva Júnior, Renato L de Carvalho, Renata G Almeida, Luisa G Rosa, Felipe Fantuzzi, Torben Rogge, Pedro M S Costa, Claudia Pessoa, Claus Jacob, Lutz Ackermann. Ruthenium(II)-Catalyzed Double Annulation of Quinones: Step-Economical Access to Valuable Bioactive Compounds. Chemistry (Weinheim an der Bergstrasse, Germany). 2020 Aug 26;26(48):10981-10986

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    PMID: 32212283

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