New relationship of E2F1 and BNIP3 with caveolin-1 in lung cancer-associated fibroblasts.

Cheng Shen, Xuanming Chen, Kai Xiao, Guowei Che

Thoracic cancer 2020 Jun

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In recent years, studies have found that E2F1, a downstream effector of caveolin-1 (Cav-1), participates in tumor cell metabolic reprogramming. E2F1 modulates mitochondrial fusion and mitophagy. Bioinformatic analysis has identified the E2F1-MFN2 axis as a regulator of mitophagy. Our data establish a new novel paradigm for regulation of the tumor cell metabolic reprogramming pathway by Cav-1 that is operationally linked and mutually dependent on the transcriptional activation of E2F1 and induces mitophagy with BNIP3 in cancer-associated fibroblasts (CAFs). © 2020 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.

Citation

Cheng Shen, Xuanming Chen, Kai Xiao, Guowei Che. New relationship of E2F1 and BNIP3 with caveolin-1 in lung cancer-associated fibroblasts. Thoracic cancer. 2020 Jun;11(6):1369-1371