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    We report chemistry suitable for the solid-phase synthesis of DNA-encoded libraries with an unusually high level of structural diversity. The strategy involves "exploding" an immobilized aldehyde into a plethora of different functional groups under DNA-compatible conditions.


    Nicholas G Paciaroni, John M Ndungu, Thomas Kodadek. Solid-phase synthesis of DNA-encoded libraries via an "aldehyde explosion" strategy. Chemical communications (Cambridge, England). 2020 Apr 30;56(34):4656-4659

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    PMID: 32215395

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