Correlation Engine 2.0
Clear Search sequence regions

  • apolipoprotein b (1)
  • chrysin (6)
  • diet (3)
  • factor (2)
  • fat (1)
  • flavonoids (2)
  • Hep (1)
  • Hnf4a (1)
  • hnf4a protein, human (1)
  • HNF4α (4)
  • humans (1)
  • lipoproteins vldl (2)
  • liver (2)
  • liver disease (5)
  • low (5)
  • MCD (3)
  • mice (5)
  • PKC (5)
  • protein human (1)
  • signal (1)
  • Sizes of these terms reflect their relevance to your search.

    We investigated the effects of chrysin (CHR) on nonalcoholic fatty liver disease (NAFLD) in mice. The NAFLD mouse model was established using a diet deficient in methionine and choline (MCD). CHR was shown to attenuate MCD-induced hepatic fat accumulation, increase very low-density lipoprotein (VLDL) secretion, and decrease hepatic oxidative stress in NAFLD mice. Inhibition of oxidative stress or direct suppression of protein kinase C (PKC) by CHR significantly reduced PKC activity in the liver, leading to a decrease in inhibitory phosphorylation of hepatocyte nuclear factor 4α (HNF4α). The resulting activation of HNF4α led to induced transcription of apolipoprotein B and VLDL secretion. Together, these results show that CHR effectively ameliorates MCD-induced fatty liver in NAFLD mice by targeting the hepatic oxidative stress/PKC/HNF4α signaling pathway. © 2020 Wiley Periodicals, Inc.


    Yu Song, Wangfei Wu, Liang Sheng, Bijie Jiang, Xiao Li, Keshu Cai. Chrysin ameliorates hepatic steatosis induced by a diet deficient in methionine and choline by inducing the secretion of hepatocyte nuclear factor 4α-dependent very low-density lipoprotein. Journal of biochemical and molecular toxicology. 2020 Jul;34(7):e22497

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 32220030

    View Full Text