FOXO1 overexpression is correlated with poor prognosis in epithelial ovarian cancer.

Longyang Liu, Juanjuan Yi, Jianhuan Yuan, Tingting Yao, Zhongqiu Lin, Yingxia Ning, Zhaoyang Zeng

Cancer biomarkers : section A of Disease markers 2020

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To investigate FOXO1 expression in epithelial ovarian cancer (EOC), and to explore its correlation with clinicopathological parameters and prognosis of EOC. Two hundred and sixteen cases of paraffin-embedded EOC and 41 paratumor tissues from 2009 to 2017 that had been pathologically confirmed at the memorial hospital of Sun Yat-sen University were included in this study, and the expression of FOXO1 was performed by immunohistochemistry using a polyclonal antibody specific for FOXO1. FOXO1 protein expression is associated with Recurrence free and overall survival in EOC patients; In addition, FOXO1 expression is associated with age, FIGO stage, intraperitoneal metastasis, intestinal metastasis, vital status, intraperitoneal recurrence and differentiation grade; Moreover, in a multivariate model FOXO1 overexpression was an independent predictor of poor survival in EOC. FOXO1 may play a candidate oncogenic role in EOC, and FOXO1 is a useful independent prognostic marker in EOC, and it may provide a candidate target therapy in future.

Citation

Longyang Liu, Juanjuan Yi, Jianhuan Yuan, Tingting Yao, Zhongqiu Lin, Yingxia Ning, Zhaoyang Zeng. FOXO1 overexpression is correlated with poor prognosis in epithelial ovarian cancer. Cancer biomarkers : section A of Disease markers. 2020;28(1):1-8