The biological implications of Yin Yang 1 in the hallmarks of cancer.

Ian Timothy Sembiring Meliala, Rendy Hosea, Vivi Kasim, Shourong Wu

Theranostics 2020

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Tumorigenesis is a multistep process characterized by the acquisition of genetic and epigenetic alterations. During the course of malignancy development, tumor cells acquire several features that allow them to survive and adapt to the stress-related conditions of the tumor microenvironment. These properties, which are known as hallmarks of cancer, include uncontrolled cell proliferation, metabolic reprogramming, tumor angiogenesis, metastasis, and immune system evasion. Zinc-finger protein Yin Yang 1 (YY1) regulates numerous genes involved in cell death, cell cycle, cellular metabolism, and inflammatory response. YY1 is highly expressed in many cancers, whereby it is associated with cell proliferation, survival, and metabolic reprogramming. Furthermore, recent studies also have demonstrated the important role of YY1-related non-coding RNAs in acquiring cancer-specific characteristics. Therefore, these YY1-related non-coding RNAs are also crucial for YY1-mediated tumorigenesis. Herein, we summarize recent progress with respect to YY1 and its biological implications in the context of hallmarks of cancer. © The author(s).

Citation

Ian Timothy Sembiring Meliala, Rendy Hosea, Vivi Kasim, Shourong Wu. The biological implications of Yin Yang 1 in the hallmarks of cancer. Theranostics. 2020;10(9):4183-4200