Correlation Engine 2.0
Clear Search sequence regions


  • fibroblast (1)
  • humans (1)
  • hydrogen ion (1)
  • minor (1)
  • photons (4)
  • responses ph (1)
  • Sizes of these terms reflect their relevance to your search.

    Novel pH probes based on 2-(6-methoxynaphthalen-2-yl)-3,3-dimethyl-3H-indole have been synthesized and characterized. These compounds display excellent "off-on" fluorescence responses to acidic pH especially under two-photon (TP) excitation conditions as well as strong selectivity and sensitivity toward H+. These features are supported by fluorescence quantum yields over 35%, TP cross sections ∼60 GM, and good resistance to photodegradation under acidic conditions. The synthetic versatility of this model allows subcellular targets to be tuned through minor scaffold modifications without affecting its optical characteristics. The effectiveness of the probes' innate photophysical properties and the structural modifications for different pH-related applications are demonstrated in mouse embryonic fibroblast cells.

    Citation

    Carlos Benitez-Martin, Juan A Guadix, John R Pearson, Francisco Najera, Jose M Perez-Pomares, Ezequiel Perez-Inestrosa. Indolenine-Based Derivatives as Customizable Two-Photon Fluorescent Probes for pH Bioimaging in Living Cells. ACS sensors. 2020 Apr 24;5(4):1068-1074

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 32227860

    View Full Text