IL-9 and IL-9-producing cells in tumor immunity.

Jie Wan, Yinqiu Wu, Xiaoyun Ji, Lan Huang, Wei Cai, Zhaoliang Su, Shengjun Wang, Huaxi Xu

Cell communication and signaling : CCS 2020 Mar 30

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Interleukin (IL)-9 belongs to the IL-2Rγc chain family and is a multifunctional cytokine that can regulate the function of many kinds of cells. It was originally identified as a growth factor of T cells and mast cells. In previous studies, IL-9 was mainly involved in the development of allergic diseases, autoimmune diseases and parasite infections. Recently, IL-9, as a double-edged sword in the development of cancers, has attracted extensive attention. Since T-helper 9 (Th9) cell-derived IL-9 was verified to play a powerful antitumor role in solid tumors, an increasing number of researchers have started to pay attention to the role of IL-9-skewed CD8+ T (Tc9) cells, mast cells and Vδ2 T cell-derived IL-9 in tumor immunity. Here, we review recent studies on IL-9 and several kinds of IL-9-producing cells in tumor immunity to provide useful insight into tumorigenesis and treatment. Video Abstract.

Citation

Jie Wan, Yinqiu Wu, Xiaoyun Ji, Lan Huang, Wei Cai, Zhaoliang Su, Shengjun Wang, Huaxi Xu. IL-9 and IL-9-producing cells in tumor immunity. Cell communication and signaling : CCS. 2020 Mar 30;18(1):50