Life, death, and autophagy in cancer: NF-κB turns up everywhere.

Daniela Verzella, Alessandra Pescatore, Daria Capece, Davide Vecchiotti, Matilde Valeria Ursini, Guido Franzoso, Edoardo Alesse, Francesca Zazzeroni

Cell death & disease 2020 Mar 30

filter terms:

Escaping programmed cell death is a hallmark of cancer. NF-κB transcription factors are key regulator of cell survival and aberrant NF-κB signaling has been involved in the pathogenesis of most human malignancies. Although NF-κB is best known for its antiapoptotic role, other processes regulating the life/death balance, such as autophagy and necroptosis, seem to network with NF-κB. This review discusses how the reciprocal regulation of NF-κB, autophagy and programmed cell death affect cancer development and progression.

Citation

Daniela Verzella, Alessandra Pescatore, Daria Capece, Davide Vecchiotti, Matilde Valeria Ursini, Guido Franzoso, Edoardo Alesse, Francesca Zazzeroni. Life, death, and autophagy in cancer: NF-κB turns up everywhere. Cell death & disease. 2020 Mar 30;11(3):210