Correlation Engine 2.0
Clear Search sequence regions

filter terms:
  • cyclic peptides (1)
  • ether (1)
  • peptaibols (3)
  • phase (2)
  • resin (3)
  • wang resin (2)
  • Sizes of these terms reflect their relevance to your search.

    Many methods have been developed for attaching an alcohol functionality to a solid support. However, not all of these methods are used to obtain peptide alcohols. In this Minireview, we will discuss several of the most important methods and approaches for the synthesis of peptide alcohols and the attachment of hydroxy groups to a solid support for the synthesis of cyclic peptides. Some of the methods include the use of functionalized Wang resin and the attachment of an alcohol to an enol ether resin. We also discuss the use of the chlorotrityl resin, one of the most common linkers used to obtain peptide alcohols. In addition, we outline the recently developed resins with the Rink, Ramage and Sieber handles. The majority of these methods have been used to synthesize many important drugs, such as octreotide and the antibiotic peptaibols. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.


    Fernando J Ferrer-Gago, Li Quan Koh. Methods and Approaches for the Solid-Phase Synthesis of Peptide Alcohols. ChemPlusChem. 2020 Apr;85(4):641-652

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 32237227

    View Full Text