Inflammation and tissue homeostasis: the NF-κB system in physiology and malignant progression.

Disruption of tissue function activates cellular stress which triggers a number of mechanisms that protect the tissue from further damage. These mechanisms involve a number of homeostatic modules, which are regulated at the level of gene expression by the transactivator NF-κB. This transcription factor shifts between activation and repression of discrete, cell-dependent gene expression clusters. Some of its target genes provide feedback to NF-κB itself, thereby strengthening the inflammatory response of the tissue and later terminating inflammation to facilitate restoration of tissue homeostasis. Disruption of key feedback modules for NF-κB in certain cell types facilitates the survival of clones with genomic aberrations, and protects them from being recognized and eliminated by the immune system, to enable thereby carcinogenesis.

Citation

George I Lambrou, Kyriaki Hatziagapiou, Spiros Vlahopoulos. Inflammation and tissue homeostasis: the NF-κB system in physiology and malignant progression. Molecular biology reports. 2020 May;47(5):4047-4063

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PMID: 32239468

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