Remodeling of collagen constituting interlobular septa of subcutaneous adipose tissue following microwaves application.

Dermatologic therapy 2020 May

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In this study, the application of a recently introduced device based on electromagnetic energy transfer by microwaves for fat reduction, permitted to study specifically the modifications of thick fibrous collagen interlobular septa in the subcutaneous adipose tissue, related to the formation of large clusters of adipocytes. The use of Picrosirius red staining associated with circularly polarized microscopy gave evidence of appreciable modifications of the fibrous connective tissue forming septa. Compact fibrotic bundles of collagen I forming interlobular septa appeared reduced or dissolved, in part substituted by the increase of more diffuse and finely reticular collagen III. Remodeling of fibrous collagen, which formed bridles involved in the appearance at the surface of the skin of dimpling/orange peer pattern typical of cellulite, was observed. © 2020 Wiley Periodicals LLC.

Citation

Nicola Zerbinati, Edoardo d'Este, Aurora Farina, Antonia I Cornaglia, Mohammad Jafferany, Masa Golubovic, Iva Binic, Julia Sigova, Nguyen Van Thuong, Michael Tirant, Federica Riva, Marina Protasoni, Raffaele Rauso, Torello Lotti, Alberto Calligaro. Remodeling of collagen constituting interlobular septa of subcutaneous adipose tissue following microwaves application. Dermatologic therapy. 2020 May;33(3):e13362