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Cancer is a rising and major health issue around the world. The acquisition of resistance to chemotherapeutic drugs is a great obstacle for the effective treatment of nearly all cancers. Drug resistance is regulated by multiple factors and mechanisms including genetic mutations, abnormal expression of some cellular transporters such as multidrug resistance (MDR) transporters, changes in apoptotic pathways, cancer stem cells, tumor microenvironment, and noncoding RNAs (ncRNAs). Evidence clearly indicates a key role for sirtuins in several characteristics of cancer drug resistance. Recent studies demonstrated the crucial impact of some ncRNAs on sirtuins expression leading to modulation of chemotherapy resistance in cancers. In this review, we will focus on the current findings about the impacts of ncRNAs on the sirtuins pathway and their role in drug resistance of cancer. Copyright © 2020 Elsevier B.V. All rights reserved.

Citation

Fatemeh Zahedipour, Khadijeh Jamialahmadi, Gholamreza Karimi. The role of noncoding RNAs and sirtuins in cancer drug resistance. European journal of pharmacology. 2020 Jun 15;877:173094

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PMID: 32243871

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