Hepatic Lipid Catabolism via PPARα-Lysosomal Crosstalk.

Rohit A Sinha, Sangam Rajak, Brijesh K Singh, Paul M Yen

International journal of molecular sciences 2020 Mar 31

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Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors which belong to the nuclear hormone receptor superfamily. They regulate key aspects of energy metabolism within cells. Recently, PPARα has been implicated in the regulation of autophagy-lysosomal function, which plays a key role in cellular energy metabolism. PPARα transcriptionally upregulates several genes involved in the autophagy-lysosomal degradative pathway that participates in lipolysis of triglycerides within the hepatocytes. Interestingly, a reciprocal regulation of PPARα nuclear action by autophagy-lysosomal activity also exists with implications in lipid metabolism. This review succinctly discusses the unique relationship between PPARα nuclear action and lysosomal activity and explores its impact on hepatic lipid homeostasis under pathological conditions such as non-alcoholic fatty liver disease (NAFLD).

Citation

Rohit A Sinha, Sangam Rajak, Brijesh K Singh, Paul M Yen. Hepatic Lipid Catabolism via PPARα-Lysosomal Crosstalk. International journal of molecular sciences. 2020 Mar 31;21(7)