Phylogeny-Guided Approach Yields Glycopeptides with Unique Action.

Ana V Cheng, William M Wuest

Trends in pharmacological sciences 2020 May

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Bacteria are extremely adept at overcoming the effects of antibiotics through a variety of mechanisms. As a result, researchers are constantly searching for antibiotics with new mechanisms of action. Culp and coworkers recently utilized a phylogeny-guided approach to mine the genomes of Actinomycetes species for glycopeptides with novel targets. Their efforts yielded the identification of complestatin and corbomycin as antibiotics with a different target than other glycopeptides. Copyright © 2020 Elsevier Ltd. All rights reserved.

Citation

Ana V Cheng, William M Wuest. Phylogeny-Guided Approach Yields Glycopeptides with Unique Action. Trends in pharmacological sciences. 2020 May;41(5):297-299