Hyperkalemic periodic paralysis aggravated by voltage - gate sodium channel blocker antiepileptic drug?

S Zukić, O Sinanović, M Alečković-Halilović, R Hodžić, L Kovačević, S Hodžić

Medical hypotheses 2020 Jun

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Hyperkalemic periodic paralysis (hyperkalemic PP) is a rare muscle disease that has onset in infancy or early childhood and is manifested by transient episodes of paralysis. In this case we presented a young male adult with attacks of weakness, after commencement of the antiepileptic drug - Carbamazepine. We hypothesize that Carbamazepine, as voltage-gate sodium channel blocker, aggravated the symptoms of hyperkalemic PP, as sodium channelopathies, in this young-male-patient, trough influence on membrane depolarization. Copyright © 2020 Elsevier Ltd. All rights reserved.

Citation

S Zukić, O Sinanović, M Alečković-Halilović, R Hodžić, L Kovačević, S Hodžić. Hyperkalemic periodic paralysis aggravated by voltage - gate sodium channel blocker antiepileptic drug? Medical hypotheses. 2020 Jun;139:109683