Correlation Engine 2.0
Clear Search sequence regions

Sizes of these terms reflect their relevance to your search.

The mechanisms underlying mammalian neural tube closure remain poorly understood. We report a unique cellular process involving multicellular rosette formation, convergent cellular protrusions, and F-actin cable network of the non-neural surface ectodermal cells encircling the closure site of the posterior neuropore, which are demonstrated by scanning electron microscopy and genetic fate mapping analyses during mouse spinal neurulation. These unique cellular structures are severely disrupted in the surface ectodermal transcription factor Grhl3 mutants that exhibit fully penetrant spina bifida. We propose a novel model of mammalian neural tube closure driven by surface ectodermal dynamics, which is computationally visualized. Copyright © 2020 Elsevier Inc. All rights reserved.


Chengji J Zhou, Yu Ji, Kurt Reynolds, Moira McMahon, Michael A Garland, Shuwen Zhang, Bo Sun, Ran Gu, Mohammad Islam, Yue Liu, Tianyu Zhao, Grace Hsu, Janet Iwasa. Non-neural surface ectodermal rosette formation and F-actin dynamics drive mammalian neural tube closure. Biochemical and biophysical research communications. 2020 Jun 04;526(3):647-653

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 32248972

View Full Text