Linkage disequilibrium and haplotype analysis of Src and Yes1 genes in thyroid cancer.

Purpose: This study was planned to examine the effects of Src and Yes1 single nucleotide polymorphism (SNPs) on the risk of thyroid cancer in 499 patients and 500 controls. Materials & methods: Three SNPs of Src gene and three SNPs of Yes1 gene were analyzed using Tetra-primer ARMS-PCR followed by sequencing. Results: rs121913314 of Src gene genotype TT showed 32-fold increased risk of thyroid cancer and rs2305994 of Yes1 genotypes TT and CT showed 2.7-fold and 16-fold increased risk in thyroid cancer (p < 0.0001). Haplotype analysis revealed that CATGCC, CATGCT, CATGTC, CATGTT, TATGCC and TATGTTA haplotypes are associated with thyroid cancer risk. Conclusion: Results showed that genotypes and allele distribution of Src and Yes1 genes are significantly linked with increased risk of thyroid cancer.

Citation

Asif Nisar, Ishrat Mahjabeen, Azhar Mehmood, Malik Waqar Ahmed, Khalida Khurshid, Mahmood Akhtar Kayani. Linkage disequilibrium and haplotype analysis of Src and Yes1 genes in thyroid cancer. Future oncology (London, England). 2020 Apr;16(12):779-792

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PMID: 32253932

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