The cytokine interleukin-1β (IL-1β) is critical for antimicrobial defenses; the inflammasome pathway typically controls IL-1β release, but pathogens often evade this pathway. In this issue, Donado et al. (2020) describe an alternative, two-cell model, to instruct inflammasome-independent IL-1β release. Published by Elsevier Inc.
Jelena S Bezbradica, Sebastian Joyce. NKT Cells Join the Two Step for Inflammasome-Independent IL-1β Release. Cell reports. 2020 Apr 07;31(1):107481
PMID: 32268100
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