Usefulness of F2-isoprostanes in early prognostication after cardiac arrest: a topical review of the literature and meta-analysis of preclinical data.

George Karlis, Anastasia Kotanidou, Georgios Georgiopoulos, Stefano Masi, Nikolaos Magkas, Theodoros Xanthos

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2020 Jun

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Prognostication after cardiac arrest (CA) represents a challenging issue, and several biomarkers have been proposed in the attempt to predict outcome. Among these, F2-isoprostanes stand out as potential biomarkers for early prognostication, providing information on the magnitude of global oxidative injury after return of spontaneous circulation (ROSC). We performed a topical review searching PubMed and Scopus databases to identify studies evaluating the modifications of F2-isoprostanes in the early period after CA, and a meta-analysis of studies providing curves of F2-isoprostanes plasma levels seeking to describe the biomarker's kinetics after CA. Evidence suggests that plasma levels of F2-isoprostanes increase in the early post-resuscitation period and seem well correlated with the burden of ischaemia-reperfusion injury. Our meta-analysis shows a possible increase as early as 5 minutes after ROSC, which persists at 2 hours and is attenuated at 4 hours. Clinical studies are warranted to evaluate the utility of this biomarker for prognostication purposes in CA survivors.

Citation

George Karlis, Anastasia Kotanidou, Georgios Georgiopoulos, Stefano Masi, Nikolaos Magkas, Theodoros Xanthos. Usefulness of F2-isoprostanes in early prognostication after cardiac arrest: a topical review of the literature and meta-analysis of preclinical data. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2020 Jun;25(4):315-321