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The pathogenesis of chronic spontaneous urticaria (CSU) is incompletely understood. There is a growing interest in the role of the coagulation cascade in chronic urticaria. Rotational thromboelastometry (ROTEM) assay enables the global assessment of coagulation status. In the present study, we aimed to test the coagulation profile in children with CSU using ROTEM and correlate these parameters with those of a healthy group. A total of 24 children with active CSU (11 girls and 13 boys) 8 to 17 years of age and age-matched and sex-matched 30 healthy control participants were enrolled in the study. ROTEM assays (intrinsic thromboelastometry and extrinsic thromboelastometry) were used to measure and analyze coagulation time, clot formation time, and maximum clot firmness. The CSU patients and controls did not differ in age, sex, erythrocyte, neutrophil, and platelet counts. Also, ROTEM parameters did not show any difference between the 2 groups. ROTEM is increasingly being used as a tool for monitoring coagulation status. In this study, ROTEM parameters did not show any difference between CSU patients and the healthy group. Further studies are needed to confirm our findings on a larger number of CSU patients. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.


Hülya Anil, Koray Harmanci, Zeynep C Özdemir, Özcan Bör, Eren Gündüz, Abdulkadir Kocak, Hilal Kaya Erdogan. Rotational Thromboelastometry Profile in Children With Chronic Spontaneous Urticaria. Journal of pediatric hematology/oncology. 2021 Mar 01;43(2):e159-e162

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PMID: 32282649

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