New Kaposi's sarcoma-associated herpesvirus variant in men who have sex with men associated with severe pathologies.

The Journal of infectious diseases 2020 Sep 14

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Kaposi sarcoma (KS)-associated herpesvirus (KSHV) subtype depends mostly on patient origin. The current study aimed to assess KSHV diversity in a population of men who have sex with men (MSM) living in France. The study included 264 patients. In 65 MSM, including 57 human immunodeficiency virus (HIV)-infected men with KS, multicentric Castleman disease, or primary effusion lymphoma and 8 HIV-uninfected men receiving HIV preexposure prophylaxis (PrEP), we performed KSHV typing with K1 open reading frame Sanger and KSHV whole-genome sequencing. In 199 other patients, we performed real-time polymerase chain reaction screening for the new variant. We found that 51% of KSHV-strains were subtype C (85% C3), and 33% were subtype A. Four patients with severe KSHV disease (2 with visceral KS, 1 with multicentric Castleman disease, and 1 with primary effusion lymphoma) and 1 asymptomatic PrEP user had a new variant resembling the Ugandan subtype F, but with different K1 open reading frame and KSHV whole-genome sequences and a different epidemiological context (MSM vs African population). Its prevalence was 4.5% in Caucasian MSM, and it was absent in other epidemiological groups. Subtype C predominated among MSM living in France. The new F variant was identified in Caucasian MSM and associated with severe KSHV disease, suggesting that subtype F could be split into F1 and F2 variants. Careful screening for this variant may be required in MSM, given the severe clinical presentation of associated diseases. © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Citation

Aude Jary, Valentin Leducq, Nathalie Desire, Héloïse Petit, Romain Palich, Véronique Joly, Ana Canestri, Adélie Gothland, Sidonie Lambert-Niclot, Laure Surgers, Corinne Amiel, Diane Descamps, Jean-Philippe Spano, Christine Katlama, Vincent Calvez, Anne-Geneviève Marcelin. New Kaposi's sarcoma-associated herpesvirus variant in men who have sex with men associated with severe pathologies. The Journal of infectious diseases. 2020 Sep 14;222(8):1320-1328