CD300a identifies a CD4+ memory T cell subset with a higher susceptibility to HIV-1 infection.

Joana Vitallé, Laura Tarancón-Díez, María R Jiménez-Leon, Iñigo Terrén, Ane Orrantia, Cristina Roca-Oporto, Luis López-Cortés, Ezequiel Ruiz-Mateos, Olatz Zenarruzabeitia, Francisco Borrego

AIDS (London, England) 2020 Jul 01

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Human CD300a is known to promote the infection by dengue and other enveloped viruses and is overexpressed on CD4 T cells from HIV-1-infected patients. We found that infected CD4+RA- T cells from untreated HIV-1-infected patients were mostly CD300a+. Furthermore, CD300a expressing CD4+RA- T cells from healthy donors were significantly more infected by HIV-1 in vitro than CD300a- cells. CD300a might represent a biomarker of susceptibility to HIV-1 infection on memory CD4 T lymphocytes.

Citation

Joana Vitallé, Laura Tarancón-Díez, María R Jiménez-Leon, Iñigo Terrén, Ane Orrantia, Cristina Roca-Oporto, Luis López-Cortés, Ezequiel Ruiz-Mateos, Olatz Zenarruzabeitia, Francisco Borrego. CD300a identifies a CD4+ memory T cell subset with a higher susceptibility to HIV-1 infection. AIDS (London, England). 2020 Jul 01;34(8):1249-1252