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Bee venom (BV) has been used for the treatment of inflammatory diseases, such as rheumatoid arthritis, and for the relief of pain in traditional oriental medicine. The aim of this study was to determine the anti-inflammatory effect of BV on monosodium urate (MSU)-induced gouty arthritis in a mouse model. To develop a mouse model of acute gouty arthritis, 4 mg 50 μL-1 of MSU crystal suspension was injected intradermally into the right paw. After MSU crystal injection, we evaluated inflammatory cytokine production in mice of the BV-treated (0.5 and 1 mg kg-1 body weight) and apamin (APM)-treated (0.5 and 1 mg kg-1 body weight) groups. The positive control group was administered a colchicine (1 mg kg-1 body weight) injection with MSU crystals. BV and APM treatment suppressed inflammatory paw edema in MSU-administered mice. It also exerted anti-inflammatory effects in mice with gouty arthritis by inhibiting proinflammatory cytokine production and inflammasome formation. Interestingly, MSU crystal formation was decreased by BV and APM treatment. These results suggest that the APM from BV might be useful for the treatment of gouty arthritis due to its anti-inflammatory activities. Copyright © 2020. Published by Elsevier B.V.


Yun Mi Lee, Soo-Na Cho, Eunjung Son, Chang-Hwa Song, Dong-Seon Kim. Apamin from bee venom suppresses inflammation in a murine model of gouty arthritis. Journal of ethnopharmacology. 2020 Jul 15;257:112860

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PMID: 32289477

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