One-Pot Iridium Catalyzed C-H Borylation/Sonogashira Cross-Coupling: Access to Borylated Aryl Alkynes.

Ghayoor A Chotana, Jose R Montero Bastidas, Susanne L Miller, Milton R Smith, Robert E Maleczka

Molecules (Basel, Switzerland) 2020 Apr 10

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Borylated aryl alkynes have been synthesized via one-pot iridium catalyzed C-H borylation (CHB)/Sonogashira cross-coupling of aryl bromides. Direct borylation of aryl alkynes encountered problems related to the reactivity of the alkyne under CHB conditions. However, tolerance of aryl bromides to CHB made possible a subsequent Sonogashira cross-coupling to access the desired borylated aryl alkynes.

Citation

Ghayoor A Chotana, Jose R Montero Bastidas, Susanne L Miller, Milton R Smith, Robert E Maleczka. One-Pot Iridium Catalyzed C-H Borylation/Sonogashira Cross-Coupling: Access to Borylated Aryl Alkynes. Molecules (Basel, Switzerland). 2020 Apr 10;25(7)