Y-Box Binding Proteins in mRNP Assembly, Translation, and Stability Control.

Daria Mordovkina, Dmitry N Lyabin, Egor A Smolin, Ekaterina M Sogorina, Lev P Ovchinnikov, Irina Eliseeva

Biomolecules 2020 Apr 11

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Y-box binding proteins (YB proteins) are DNA/RNA-binding proteins belonging to a large family of proteins with the cold shock domain. Functionally, these proteins are known to be the most diverse, although the literature hardly offers any molecular mechanisms governing their activities in the cell, tissue, or the whole organism. This review describes the involvement of YB proteins in RNA-dependent processes, such as mRNA packaging into mRNPs, mRNA translation, and mRNA stabilization. In addition, recent data on the structural peculiarities of YB proteins underlying their interactions with nucleic acids are discussed.

Citation

Daria Mordovkina, Dmitry N Lyabin, Egor A Smolin, Ekaterina M Sogorina, Lev P Ovchinnikov, Irina Eliseeva. Y-Box Binding Proteins in mRNP Assembly, Translation, and Stability Control. Biomolecules. 2020 Apr 11;10(4)