One new spirocyclic lactone and one new benzopyran derivative from Aspergillus terreus.

One new spirocyclic lactone, terreinlactone C (1), and one new benzopyran derivative, 2,2-dimethyl-3-hydroxychroman-6-aldehyde (2), were discovered from the fungus Aspergillus terreus. The chemical structures of compounds 1 and 2 were elucidated by detailedly analyzing NMR and HRESIMS data. Compound 1 is the first natural product with a 1-oxaspiro[4.5]decan-2-one ring system and a possible biogenetic pathway is proposed. Two compounds were tested for their cytotoxic activities against five human cancer cell lines.[Formula: see text].

Citation

Dong-Yan Li, Pan Han, Zhao-Di Wu, Chun-Mei Chen, Qing-Yi Tong, Hu-Cheng Zhu, Jie-Ru Guo, Yong-Ji Lai, Yong-Hui Zhang. One new spirocyclic lactone and one new benzopyran derivative from Aspergillus terreus. Journal of Asian natural products research. 2021 May;23(5):429-435

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PMID: 32290693

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