Mechanisms and consequences of subcellular RNA localization across diverse cell types.

Krysta L Engel, Ankita Arora, Raeann Goering, Hei-Yong G Lo, J Matthew Taliaferro

Traffic (Copenhagen, Denmark) 2020 Jun

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Essentially all cells contain a variety of spatially restricted regions that are important for carrying out specialized functions. Often, these regions contain specialized transcriptomes that facilitate these functions by providing transcripts for localized translation. These transcripts play a functional role in maintaining cell physiology by enabling a quick response to changes in the cellular environment. Here, we review how RNA molecules are trafficked within cells, with a focus on the subcellular locations to which they are trafficked, mechanisms that regulate their transport and clinical disorders associated with misregulation of the process. © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Citation

Krysta L Engel, Ankita Arora, Raeann Goering, Hei-Yong G Lo, J Matthew Taliaferro. Mechanisms and consequences of subcellular RNA localization across diverse cell types. Traffic (Copenhagen, Denmark). 2020 Jun;21(6):404-418