Microfluidic devices for neutrophil chemotaxis studies.

Neutrophil chemotaxis plays a vital role in human immune system. Compared with traditional cell migration assays, the emergence of microfluidics provides a new research platform of cell chemotaxis study due to the advantages of visualization, precise control of chemical gradient, and small consumption of reagents. A series of microfluidic devices have been fabricated to study the behavior of neutrophils exposed on controlled, stable, and complex profiles of chemical concentration gradients. In addition, microfluidic technology offers a promising way to integrate the other functions, such as cell culture, separation and analysis into a single chip. Therefore, an overview of recent developments in microfluidic-based neutrophil chemotaxis studies is presented. Meanwhile, the strength and drawbacks of these devices are compared.

Citation

Wenjie Zhao, Haiping Zhao, Mingxiao Li, Chengjun Huang. Microfluidic devices for neutrophil chemotaxis studies. Journal of translational medicine. 2020 Apr 15;18(1):168

Mesh Tags

PMID: 32293474

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