Enhancing WNT Signaling Restores Cortical Neuronal Spine Maturation and Synaptogenesis in Tbr1 Mutants.

Siavash Fazel Darbandi, Sarah E Robinson Schwartz, Emily Ling-Lin Pai, Amanda Everitt, Marc L Turner, Benjamin N R Cheyette, A Jeremy Willsey, Matthew W State, Vikaas S Sohal, John L R Rubenstein

Cell reports 2020 Apr 14

filter terms:

Tbr1 is a high-confidence autism spectrum disorder (ASD) gene encoding a transcription factor with distinct pre- and postnatal functions. Postnatally, Tbr1 conditional knockout (CKO) mutants and constitutive heterozygotes have immature dendritic spines and reduced synaptic density. Tbr1 regulates expression of several genes that underlie synaptic defects, including a kinesin (Kif1a) and a WNT-signaling ligand (Wnt7b). Furthermore, Tbr1 mutant corticothalamic neurons have reduced thalamic axonal arborization. LiCl and a GSK3β inhibitor, two WNT-signaling agonists, robustly rescue the dendritic spines and the synaptic and axonal defects, suggesting that this could have relevance for therapeutic approaches in some forms of ASD. Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.

Citation

Siavash Fazel Darbandi, Sarah E Robinson Schwartz, Emily Ling-Lin Pai, Amanda Everitt, Marc L Turner, Benjamin N R Cheyette, A Jeremy Willsey, Matthew W State, Vikaas S Sohal, John L R Rubenstein. Enhancing WNT Signaling Restores Cortical Neuronal Spine Maturation and Synaptogenesis in Tbr1 Mutants. Cell reports. 2020 Apr 14;31(2):107495