Anxiolytic-Like Action of Selected 4-(Alkylamino)-3-nitrocoumarin Derivatives in BALB/c Mice.

Pavle J Randjelović, Niko S Radulović, Nikola M Stojanović, Vidoslav S Dekić, Biljana R Dekić, Nenad I Stojiljković, Sonja M Ilić

Chemistry & biodiversity 2020 Jun

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In this work, we explored the possible polypharmacological potential of the already established antimicrobials against gastrointestinal pathogens, 4-(alkylamino)-3-nitrocoumarins, as antianxiety agents, using a battery of in vivo experiments. Three chosen coumarin derivatives, differing in the substituent (sec-butylamino, hexadecylamino, or benzylamino) at position 4, at the doses of 25, 50 and 100 mg kg-1 , were evaluated in light/dark, open-field, horizontal wire and diazepam-induced sleep models using male BALB/c mice. Depending on the applied dose, all three tested coumarins displayed a noteworthy anxiolytic-like effect. 4-(sec-Butylamino)-3-nitro-2H-chromen-2-one and 4-(hexadecylamino)-3-nitro-2H-chromen-2-one could be recognized as true anxiolytics in the lowest applied dose, based on three tests, without exerting any sedative effects. Thus, the 3-nitrocoumarin core deserves further chemical diversity exploration in the 'antianxiety' direction. © 2020 Wiley-VHCA AG, Zurich, Switzerland.

Citation

Pavle J Randjelović, Niko S Radulović, Nikola M Stojanović, Vidoslav S Dekić, Biljana R Dekić, Nenad I Stojiljković, Sonja M Ilić. Anxiolytic-Like Action of Selected 4-(Alkylamino)-3-nitrocoumarin Derivatives in BALB/c Mice. Chemistry & biodiversity. 2020 Jun;17(6):e2000206