Construction of hybrid DNAs@CP for the rapid synchronous sensing of multiplex microRNAs based on experimental studies and molecular simulation.

A water stable one-dimensional (1D) ladder-shaped coordination polymer (CP) has been synthesized and exhibits a strong affinity to two fluorescein-tagged single-stranded probe DNAs (P-DNAs), giving a sensing platform of P-DNAs@1. Such a hybrid sensing platform is capable of simultaneous detection of breast cancer related microRNA-221 (miRNA-221) and miRNA-222 in a specific and synchronous manner, without observable cross-reactions, as supported by experimental evidences. The interaction mode and the electronic energy between CP 1 with nucleic acid were confirmed by molecular simulation and the universal force field (UFF). Copyright © 2020 Elsevier Inc. All rights reserved.

Citation

Zi-Chuan Yang, Tao-Rui Wang, Rong-Tian Li, Ting-Wei Chen, Yue Fan, Wei-Hua Jiang, Min-Min Li, Jin-Xiang Chen. Construction of hybrid DNAs@CP for the rapid synchronous sensing of multiplex microRNAs based on experimental studies and molecular simulation. Journal of inorganic biochemistry. 2020 Jul;208:111076

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PMID: 32304915

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