Depletion of langerin+ cells enhances cutaneous wound healing.

Aarthi Rajesh, Gabriella Stuart, Nicola Real, Jenny Ahn, Allison Tschirley, Lyn Wise, Merilyn Hibma

Immunology 2020 Aug

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Langerin is a C-type lectin receptor that is expressed on Langerhans cells and langerin-positive dermal dendritic cells in the skin. Little is known about the function of langerin+ cells in wound healing. In this study, the effects of ablation of langerin+ cells on healing of a full-thickness excision wound were investigated using the langerin-DTR depletable mouse. Strikingly, depletion of langerin+ cells resulted in more rapid reduction in wound area. Accelerated wound healing in the langerin+ -cell-depleted group was characterized by enhanced neo-epidermis and granulation tissue formation, and increased cellular proliferation within the newly formed tissues. Accelerated healing in the absence of langerin+ cells was associated with increased levels of granulocyte-macrophage colony-stimulating factor, F4/80+ cells and blood vessels within the granulation tissue. These data support an inhibitory role for langerin+ cells during wound healing. Therapies that suppress langerin+ cells or their function may therefore have utility in progressing the healing of wounds in humans. © 2020 John Wiley & Sons Ltd.

Citation

Aarthi Rajesh, Gabriella Stuart, Nicola Real, Jenny Ahn, Allison Tschirley, Lyn Wise, Merilyn Hibma. Depletion of langerin+ cells enhances cutaneous wound healing. Immunology. 2020 Aug;160(4):366-381