Interface dermatitis as an indicator of hepatic involvement in drug reaction with eosinophilia and systemic symptoms (DRESS).

Sarita Sasidharanpillai, Aparna Govindan, Kidangazhiathmana Ajithkumar, Anuradha Thalian Chathoth, Anza Khader, Olassery Kalathingal Reena Mariyath, Ruba Farsha, Najiya Sherin, Effeena Merin David

Journal of cutaneous pathology 2020 Sep

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There are conflicting reports on the association between interface dermatitis and hepatic involvement in DRESS. A cross-sectional analysis of the clinical and the histopathologic features of DRESS was performed to study the association between the histopathology of the skin rash and hepatic involvement. The clinical and the histopathologic findings were evaluated in 40 cases of DRESS. Thirty patients (75%) had a hepatic involvement. Thirty (75%) biopsy specimens showed a combination of different inflammatory patterns. The interface dermatitis was noted in 24 specimens (60%). Twenty-one patients with the interface dermatitis had a hepatic involvement (P = .04). The skin rash of DRESS often shows the coexistence of different inflammatory patterns. The interface dermatitis showed a statistically significant association with the hepatic involvement in DRESS. © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Citation

Sarita Sasidharanpillai, Aparna Govindan, Kidangazhiathmana Ajithkumar, Anuradha Thalian Chathoth, Anza Khader, Olassery Kalathingal Reena Mariyath, Ruba Farsha, Najiya Sherin, Effeena Merin David. Interface dermatitis as an indicator of hepatic involvement in drug reaction with eosinophilia and systemic symptoms (DRESS). Journal of cutaneous pathology. 2020 Sep;47(9):800-808