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HotSpot3D is a widely used software for identifying mutation hotspots on the 3D structures of proteins. To further assist users, we developed a new HotSpot3D web server to make this software more versatile, convenient and interactive. The HotSpot3D web server performs data pre-processing, clustering, visualization and log-viewing on one stop. Users can interactively explore each cluster and easily re-visualize the mutational clusters within browsers. We also provide a database that allows users to search and visualize proximal mutations from 33 cancers in the Cancer Genome Atlas. Supplementary data are available at Bioinformatics online. © The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail:


Shanyu Chen, Xiaoyu He, Ruilin Li, Xiaohong Duan, Beifang Niu. HotSpot3D web server: an integrated resource for mutation analysis in protein 3D structures. Bioinformatics (Oxford, England). 2020 Jun 01;36(12):3944-3946

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PMID: 32315389

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