Recent progress of 1,3,4-oxadiazoles as anticonvulsants: Future horizons.

Epilepsy is the most common neurological disorder, which affects more than 50 million people worldwide. Despite the development and use of several antiepileptic drugs (AEDs), attempted seizure control fails in almost 30% of the individuals treated. Other patients benefit from seizure control by drug therapy at the expense of dose-related toxicity and side effects. These drawbacks with conventional AEDs demand the need for developing more effective and safer antiseizure agents. As a result, extensive efforts are devoted to design and develop new effective molecules as antiepileptics. This area of research to find more effective and safer AEDs is important and challenging. This review describes the future perspective of various 1,3,4-oxadiazole derivatives as anticonvulsant agents and focuses on the design and development of the new effective molecule. © 2020 Deutsche Pharmazeutische Gesellschaft.

Citation

Shagufi Nazar, Nadeem Siddiqui, Ozair Alam. Recent progress of 1,3,4-oxadiazoles as anticonvulsants: Future horizons. Archiv der Pharmazie. 2020 Jul;353(7):e1900342

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PMID: 32319117

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