Sc(OTf)3-Mediated One-Pot Synthesis of 2,3-Disubstituted Quinolines from Anilines and Epoxides.

Md Shafaat Al Mehedi, Jetze J Tepe

The Journal of organic chemistry 2020 May 15

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Here, we report the first synthesis of 2,3-disubstituted quinolines from anilines and aromatic or aliphatic epoxides. This reaction utilizes Sc(OTf)3 as a Lewis acid and TEMPO as an oxygen scavenger. A wide variety of highly substituted quinolines were obtained with moderate to excellent yields (up to 96%).

Citation

Md Shafaat Al Mehedi, Jetze J Tepe. Sc(OTf)3-Mediated One-Pot Synthesis of 2,3-Disubstituted Quinolines from Anilines and Epoxides. The Journal of organic chemistry. 2020 May 15;85(10):6741-6746