Guangcheng Zu, Xiuhai Gan, Dandan Xie, Huanyu Yang, Awei Zhang, Shaoyuan Li, Deyu Hu, Baoan Song
Journal of agricultural and food chemistry 2020 May 20Tomato chlorosis virus (ToCV) has caused great harm to the production of tomato worldwide. To develop efficient anti-ToCV agents, some novel 4(3H)-quinazolinone derivatives containing dithioacetal were designed and synthesized, and their anti-ToCV activities were evaluated by microscale thermophoresis (MST) using ToCV coat protein (ToCV-CP) as a new target. The results showed that some compounds had a strong binding capacity to ToCV-CP. In particular, compounds C5 and C22 have an excellent binding capacity to ToCV-CP, with binding constant values of 0.24 and 0.25 μM, respectively. Additionally, reduced ToCV-CP gene expression levels of 81.05 and 87.59% could be achieved when tomato was treated with compounds C5 and C22, respectively, which were obviously higher than the levels after ningnanmycin (NNM) treatment (43.88%) and lead compound Xiangcaoliusuobingmi (XCLSBM) treatment (63.56%). Therefore, this work indicates that 4(3H)-quinazolinone derivatives containing dithioacetal moiety can be used as novel anti-ToCV agents.
Guangcheng Zu, Xiuhai Gan, Dandan Xie, Huanyu Yang, Awei Zhang, Shaoyuan Li, Deyu Hu, Baoan Song. Design, Synthesis, and Anti-ToCV Activity of Novel 4(3H)-Quinazolinone Derivatives Bearing Dithioacetal Moiety. Journal of agricultural and food chemistry. 2020 May 20;68(20):5539-5544
PMID: 32323987
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