Conformational Studies of Oligosaccharides.

Yang Yu, Martina Delbianco

Chemistry (Weinheim an der Bergstrasse, Germany) 2020 Aug 06

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The conformation of a molecule strongly affects its function, as demonstrated for peptides and nucleic acids. This correlation is much less established for carbohydrates, the most abundant organic materials in nature. Recent advances in synthetic and analytical techniques have enabled the study of carbohydrates at the molecular level. Recurrent structural features were identified as responsible for particular biological activities or material properties. In this Minireview, recent achievements in the structural characterization of carbohydrates, enabled by systematic studies of chemically defined oligosaccharides, are discussed. These findings can guide the development of more potent glycomimetics. Synthetic carbohydrate materials by design can be envisioned. © 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.

Citation

Yang Yu, Martina Delbianco. Conformational Studies of Oligosaccharides. Chemistry (Weinheim an der Bergstrasse, Germany). 2020 Aug 06;26(44):9814-9825