Correlation Engine 2.0
Clear Search sequence regions

  • b lymphocytes (17)
  • Bmi1 (14)
  • bone marrow (2)
  • cellular (1)
  • Kdm5b (1)
  • liver (1)
  • lymphocytes (1)
  • lymphopoiesis (2)
  • mice (3)
  • mice nod (1)
  • mice scid (1)
  • Polycomb (2)
  • repress (1)
  • rna (1)
  • stem cells (1)
  • stem cells lymphoid (1)
  • Sizes of these terms reflect their relevance to your search.

    The self-renewal ability is a unique property of fetal-derived innate-like B-1a lymphocytes, which survive and function without being replenished by bone marrow (BM) progenitors. However, the mechanism by which IgM-secreting mature B-1a lymphocytes self-renew is poorly understood. In this study, we showed that Bmi1 was critically involved in this process. Although Bmi1 is considered essential for lymphopoiesis, the number of mature conventional B cells was not altered when Bmi1 was deleted in the B cell lineage. In contrast, the number of peritoneal B-1a cells was significantly reduced. Peritoneal cell transfer assays revealed diminished self-renewal ability of Bmi1-deleted B-1a cells, which was restored by additional deletion of Ink4-Arf, the well-known target of Bmi1 Fetal liver cells with B cell-specific Bmi1 deletion failed to repopulate peritoneal B-1a cells, but not other B-2 lymphocytes after transplantation assays, suggesting that Bmi1 may be involved in the developmental process of B-1 progenitors to mature B-1a cells. Although Bmi1 deletion has also been shown to alter the microenvironment for hematopoietic stem cells, fat-associated lymphoid clusters, the reported niche for B-1a cells, were not impaired in Bmi1 -/- mice. RNA expression profiling suggested lysine demethylase 5B (Kdm5b) as another possible target of Bmi1, which was elevated in Bmi1-/- B-1a cells in a stress setting and might repress B-1a cell proliferation. Our work has indicated that Bmi1 plays pivotal roles in self-renewal and maintenance of fetal-derived B-1a cells. Copyright © 2020 by The American Association of Immunologists, Inc.


    Michihiro Kobayashi, Yang Lin, Akansha Mishra, Chris Shelly, Rui Gao, Colton W Reeh, Paul Zhiping Wang, Rongwen Xi, Yunlong Liu, Pamela Wenzel, Eliver Ghosn, Yan Liu, Momoko Yoshimoto. Bmi1 Maintains the Self-Renewal Property of Innate-like B Lymphocytes. Journal of immunology (Baltimore, Md. : 1950). 2020 Jun 15;204(12):3262-3272

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 32332108

    View Full Text