Development of a stereo dip-coating system for fabrication of tube-shaped blood vessel models.

Yasutomo Shimizu, Simon Tupin, Chihaya Kiyomitsu, Ko Kitamura, Kazuto Takashima, Makoto Ohta

Scientific reports 2020 Apr 24

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Tube-shaped blood vessel models that mimic their geometries and mechanical properties can deliver reliable and realistic behavioral information such as deformation and rupture during procedures such as insertion of medical devices. Thickness of vessel walls is an important parameter for fabricating the blood vessel models owing to their strong influence on the model behavior, especially during deformation. The dip-coating method is used to fabricate blood vessel models; however, non-uniform wall thicknesses are observed using this method. This study aimed at finding the characteristics of stereo "angular control dip-coating" (ACDC) system to develop a dip-coating system that can produce tubular models with uniformed wall thickness. The system developed here enables an observation of the substrate behavior from two different views. The conditions of dip-coating used in this study produce 1.36-1.82 mm in the maximum and 0.188-0.435 mm in minimum wall thickness and the fabricated walls cover the realistic range of carotid arterial dimensions. The characteristics of the ACDC system indicate that ACDC is effective for fabricating the uniform wall thickness particularly in the strong curved parts.

Citation

Yasutomo Shimizu, Simon Tupin, Chihaya Kiyomitsu, Ko Kitamura, Kazuto Takashima, Makoto Ohta. Development of a stereo dip-coating system for fabrication of tube-shaped blood vessel models. Scientific reports. 2020 Apr 24;10(1):6929