Solubility of codeine phosphate in carbitol + 2-propanol mixture at different temperatures.

Homa Rezaei, Abolghasem Jouyban, Fleming Martinez, Mohammad Barzegar-Jalali, Elaheh Rahimpour

Drug development and industrial pharmacy 2020 Jun

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The solubility profile of codeine phosphate in the carbitol and 2-propanol mixtures at 293.2-313.2 K are determined and correlated with some developed cosolvency models. Moreover, the density values of codeine phosphate saturated solutions are also determined and fitted with the Jouyban-Acree model. The model accuracy is investigated by calculating the mean relative deviations (MRDs%). The thermodynamic parameters of codeine phosphate dissolution in the non-aqueous mixtures of carbitol and 2-propanol are also computed by using van't Hoff and Gibbs equations.

Citation

Homa Rezaei, Abolghasem Jouyban, Fleming Martinez, Mohammad Barzegar-Jalali, Elaheh Rahimpour. Solubility of codeine phosphate in carbitol + 2-propanol mixture at different temperatures. Drug development and industrial pharmacy. 2020 Jun;46(6):910-915