Regulating the regulator: nitric oxide control of post-translational modifications.

Nitric oxide (NO) is perfectly suited for the role of a redox signalling molecule. A key route for NO bioactivity occurs via protein S-nitrosation, and involves the addition of a NO moiety to a protein cysteine (Cys) thiol (-SH) to form an S-nitrosothiol (SNO). This process is thought to underpin a myriad of cellular processes in plants that are linked to development, environmental responses and immune function. Here we collate emerging evidence showing that NO bioactivity regulates a growing number of diverse post-translational modifications including SUMOylation, phosphorylation, persulfidation and acetylation. We provide examples of how NO orchestrates these processes to mediate plant adaptation to a variety of cellular cues. ©2020 The Authors. New Phytologist ©2020 New Phytologist Trust.

Citation

Kapuganti Jagadis Gupta, Zsuzsanna Kolbert, Jorg Durner, Christian Lindermayr, Francisco J Corpas, Renaud Brouquisse, Juan B Barroso, Saima Umbreen, José M Palma, John T Hancock, Marek Petrivalsky, David Wendehenne, Gary J Loake. Regulating the regulator: nitric oxide control of post-translational modifications. The New phytologist. 2020 Sep;227(5):1319-1325

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PMID: 32339293

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