Emergence of Mycobacterium leprae Rifampin Resistance Evaluated by Whole-Genome Sequencing after 48 Years of Irregular Treatment.
Charlotte Avanzi, Raquel Cristina Maia, Andrej Benjak, José Augusto Nery, Anna Maria Sales, Alice Miranda, Nadia Cristina Duppre, Amanda Nogueira Brum Fontes, Tatiana Pereira da Silva, Roberta Olmo Pinheiro, Fernanda Neves-Manta, Suelen Justo Maria Moreira, Philippe Busso, Euzenir Nunes Sarno, Phillip Noel Suffys, Stewart Thomas Cole, Milton Ozório Moraes
Antimicrobial agents and chemotherapy 2020 Jun 23A case of Mycobacterium leprae rifampin resistance after irregular antileprosy treatments since 1971 is reported. Whole-genome sequencing from four longitudinal samples indicated relapse due to acquired rifampin resistance and not to reinfection with another strain. A putative compensatory mutation in rpoC was also detected. Clinical improvement was achieved using an alternative therapy. Copyright © 2020 American Society for Microbiology.
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Charlotte Avanzi, Raquel Cristina Maia, Andrej Benjak, José Augusto Nery, Anna Maria Sales, Alice Miranda, Nadia Cristina Duppre, Amanda Nogueira Brum Fontes, Tatiana Pereira da Silva, Roberta Olmo Pinheiro, Fernanda Neves-Manta, Suelen Justo Maria Moreira, Philippe Busso, Euzenir Nunes Sarno, Phillip Noel Suffys, Stewart Thomas Cole, Milton Ozório Moraes. Emergence of Mycobacterium leprae Rifampin Resistance Evaluated by Whole-Genome Sequencing after 48 Years of Irregular Treatment. Antimicrobial agents and chemotherapy. 2020 Jun 23;64(7)
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PMID: 32340990
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