Cytoskeleton Architecture Regulates Glycolysis Coupling Cellular Metabolism to Mechanical Cues.

Alisdair R Fernie, Youjun Zhang, Arun Sampathkumar

Trends in biochemical sciences 2020 Aug

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Energy-demanding processes, such as cell growth, migration, and differentiation, are tension modulated, begging the question whether metabolism and mechanical tension are tightly linked. A recent report by Park et al. shows that stiffness in the extracellular matrix (ECM) promotes reorganization of actin, resulting in enhanced glycolysis. Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.

Citation

Alisdair R Fernie, Youjun Zhang, Arun Sampathkumar. Cytoskeleton Architecture Regulates Glycolysis Coupling Cellular Metabolism to Mechanical Cues. Trends in biochemical sciences. 2020 Aug;45(8):637-638